2020 should go down in history as the beginning of a new era – ‘The age of infectious diseases.' Ever since COVID-19, new infectious diseases have cropped up at a rate that precludes giving us breathing space. Obviously, no one told these guys about boundaries. Langya virus is one recent addition to the mix, identified as a novel zoonotic henipavirus in China. This virus is part of a genus that has been linked to severe health threats in humans and animals alike, including its more infamous relatives, Hendra virus and Nipah virus, both of which have caused significant outbreaks in various regions of the world [1]. If you are bemoaning the state of the world because you just cannot take another virus, it is time you got personal with Langya.
1. Where Is the Fire?
The Langya henipavirus (LayV) originated in China and belongs to the henipavirus genus that has been traced back to animals, with fruit bats being the commonest source. Starting to notice a pattern here? Now we could be wrong, but we bet Batman rues the day he picked his name. In this case, though, the actual virus-harboring animal is the shrew, a mole-like mammal. Despite the unfortunate name and the even more unfortunate show of diseased hands, these guys are real cuties. Moral of the story: do not judge a book by its cover. Also, do not keep shrews for pets. While we are on the subject, the virus was also found in a small percentage of dogs and goats, indicating a broader animal reservoir that could have implications for spillover events [5]. So pet lovers, beware!
2. The Lineage
LayV comes from a long, illustrious line of havoc-wreaking viruses. If the name ‘henipavirus' does nothing to jog your memory, try removing the “he” from the beginning. Sound familiar? Yeah, now we're getting closer (enter Nipah virus). LayV and Nipah virus share the same family and exhibit similar traits, but luckily for us, they differ significantly in terms of virulence. Current research suggests that Langya virus is less pathogenic than Nipah virus, particularly since there is as yet no evidence that it can be transmitted between humans [2]. Animals remain the primary source of infection, so if you have not been keeping company with shrews (the animals, not people fitting that description) lately, you can relax.
3. Timeline Twist
The twist in this viral tale? The 35 farmers who were diagnosed with this condition were all affected in a short time frame. Given that LayV has only just earned its place on the bad boy list, the timeline could inspire worry. However, this is actually good news – it indicates that the disease has barely made a dent in the last several years [4]. If you were looking for confirmation of an epidemic or pandemic, so you can start panic-buying and crawl under a rock, sorry. This one is pretty straightforward, unlike its cousin Nipah.
4. Symptom Breakdown
The symptoms of LayV are not too different from most other zoonotic viruses, but you can keep this list in mind, should you ever suspect LayV: Fever, leukopenia (low white blood cell count), fatigue, cough, and muscle aches were the commonest symptoms reported (in that order of prevalence), while nausea, vomiting, and headaches also occurred. Thrombocytopenia (low platelet count), along with impaired liver and kidney functions, have been noted in some cases [3].
5. To Run or Not to Run?
No, you do not have to run and hide, because the zoonotic nature, absence of human-to-human transmission, and zero fatalities associated with Langya thus far mean that there is hope [2]. Most experts think there is no real danger of this turning into the next big event of the century (one pandemic is enough, thank you). However, there is no guarantee that this will not evolve, as viruses have a tendency to mutate over time. But for now, no worries.
For the record, Langya is worth some attention but definitely not worth paranoia. If you must invest in virus-bashing and sleepless nights, maybe practice moderation! Stay cautious, keep away from shrews and bats, but do not let one measly virus get you down.
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References:
- Xinyu Qiu, Feng Wang, Ailong Sha. Infection and transmission of henipavirus in animals.. PubMed. 2024.
- Pratik Talukdar, Debankita Dutta, Elija Ghosh, Indrani Bose, Sourish Bhattacharjee. Molecular Pathogenesis of Nipah Virus.. PubMed. 2023.
- Jorge Quarleri, Verónica Galvan, M Victoria Delpino. Henipaviruses: an expanding global public health concern?. PubMed. 2022.
- Chad E Mire, Benjamin A Satterfield, Thomas W Geisbert. Nonhuman Primate Models for Nipah and Hendra Virus Countermeasure Evaluation.. PubMed. 2023.
- Ranjit Sah, Aroop Mohanty, Sandip Chakraborty, Kuldeep Dhama. Langya virus: A newly identified zoonotic henipavirus.. PubMed. 2022.